![]() ![]() ![]() Blood pressure on admission was 140/77 mmHg. A clinical neurologic examination on admission revealed disorientation in all qualities, retrograde amnesia, and reduced tendon reflexes but was otherwise normal. He was regularly taking candesartan and bisoprolol. He had a previous history of arterial hypertension, myocarditis due to borreliosis with systolic dysfunction that was diagnosed 13 years prior to the current admission, and an allergy to penicillin. Our patient is a 64-year-old white man, height 176 cm, weight 90 kg, who developed a sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law to whom he had a close emotional relation. Whether pre-existing myocardial compromise promotes the development of Takotsubo syndrome requires further investigations. A possible common pathomechanism could be overstimulation of adrenergic receptors in the myocardium, the cerebrum, or the coronary or cerebral arteries. A possible trigger for both conditions could be severe emotional stress from the loss of a close relative. Since Takotsubo syndrome may be associated with transient global amnesia a causal relation may exist. Since coronary angiography was normal and electrocardiography and echocardiographic abnormalities resolved under candesartan, bisoprolol, acetyl-salicylic acid, and atorvastatin within a few days after onset, Takotsubo syndrome was diagnosed. Upon transthoracic echocardiography the apical type of a Takotsubo syndrome was suspected. Electrocardiography showed left anterior hemiblock and negative T-waves in V2–V6. Blood tests revealed moderate renal insufficiency, elevated troponin-T, and elevated N-terminal prohormone of brain natriuretic peptide. Upon neurological work-up and after spontaneous resolution of most of the neurological deficits, transient global amnesia was diagnosed. Our patient is a 64-year-old white man with a previous history of myocarditis from borreliosis who developed sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome. Simultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. ![]()
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